In Buenos Aires, Gleizer would do business in various lines of business before specializing in the sale of books. In 1920 he opened the La Cultura bookstore, near the current corner of Scalabrini Ortiz and Corrientes, which became one of the centers of literary life in Buenos Aires. In 1922 Gleizer began his publishing career, editing Joaquín de Vedia's How I saw them. Gleizer's books - printed in The Invincible, the printing house of César Tiempo's family - were organized into three collections: one dedicated to Jewish subjects, another to current political issues, and a third, general, in which many of them would appear. the most outstanding works. Following the re- commendations of La Cultura regulars, Gleizer published a large number of hitherto unknown authors, and professionalized the editor's work by dealing with the layout, composition, art and distribution of the books. Among the authors that appeared in the Gleizer collection were Jorge Luis Borges, Arturo Cancela, Carlos De la Púa, Samuel Eichelbaum, Vicente Fatone, Macedonio Fernández, Jacobo Fijman, Luís Franco, Alberto Gerchunoff, Manuel Gálvez, the González Tuñón brothers, Leopoldo Lugones, Eduardo Mallea, Leopoldo Marechal, Roberto Mariani, Nicolas Olivari, Alfredo Palacios, Roberto Payró, Raúl Scalabrini Ortiz, César Tempo, Alberto Vacarezza, and Florencio Varela. The last work he edited was Megatón, by Bernardo Verbitzky (1962).