He works in animal models of mitochondrial DNA damage and oxidative stress. The Melov lab takes a multidisciplinary geroscience approach to better understand the core mechanisms that drive aging. This includes a heavy reliance on multiple model systems, including invertebrate models, mammalian models (the laboratory mouse), human cell lines and tissues, and state-of-the-art genomic technologies that rely on heavy computational methods to better understand how cells and tissues change with age and/or pharmacological intervention.