Anne was appointed as Lecturer at the University of Liverpool in 2001 and as Professor in the Faculty of Health and Life Sciences at the University of Liverpool in 2007. She is currently acting Head of the Department of Musculoskeletal Biology II. Anne is past Chair of the British Society for Research on Ageing and the British Council for Ageing. She is an active member of the American Physiological Society and the UK Physiological Society and Biochemical Society. Professor McArdle is Associate Editor for the American Journal of Physiology, International Advisor on the Environmental & Exercise Physiology Committee of the American Physiological Society and a core member of BBSRC Grant Committee A. Professor McArdle’s work on frailty has received considerable public interest with press releases and presentation of our applied work to the general public at several events. As School Director of Postgraduate Research, Anne led a complete overhaul of student monitoring and support procedures within the School which has led to substantial improvements in the student experience.Professor McArdle’s research interests include the basic processes by which cells respond and adapt to stress and damage and in particular, the role that the age-related failure in the stress response plays in the development of age-related skeletal muscle dysfunction and has made key observations in this area of research. Her research group has demonstrated the importance of rapid induction of responses to the increased ROS generated by contractions in maintaining muscle viability and the role that attenuation of these ROS signals and responses play in muscle ageing. Anne has considerable experience of cell and molecular biological studies at the subcellular level through to physiological analysis of muscle function in a number of model systems including cell culture, animal models and in humans.