Manlio Vinciguerra is a Principal Investigator at the International Clinical Research Center (ICRC), Brno, Czech Republic. Previously he held a position of Senior Lecturer at the Institute for Liver and Digestive Health at the University College London (UCL), London, United Kingdom. Vinciguerra unraveled important cellular signaling and epigenetics mechanisms involved in metabolic and infectious processes, stress and aging in the heart and in the liver, such as PI3K/AKT/mTOR pathway and sirtuins, using a systems biology approach in cells and rodent models. He is a member of Who's Who in Gerontology. Principal Investigator in epigenetics, nutrition and gastroenterology. He is the founder and CSO of P4LifeTech