Deborah Louise McGuinness (born ca. 1960) is an American computer scientist and researcher at Rensselaer Polytechnic Institute (RPI). She is a professor of Computer, Cognitive and Web Sciences, Industrial and Systems Engineering, and an endowed chair in the Tetherless World Constellation, a multidisciplinary research institution within RPI that focuses on the study of theories, methods and applications of the World Wide Web. Her fields of expertise include interdisciplinary data integration, artificial intelligence, specifically in knowledge representation and reasoning, description logics, the semantic web, explanation, and trust.