Bert Vogelstein is director of the Ludwig Center, Clayton Professor of Oncology and Pathology and a Howard Hughes Medical Institute investigator at The Johns Hopkins Medical School and Sidney Kimmel Comprehensive Cancer Center. Bert Vogelstein, M.D., made history as the first scientist to uncover the molecular underpinnings of a common human cancer. Through his groundbreaking research, he and his colleagues demonstrated how colorectal tumors arise from the gradual accumulation of genetic alterations in oncogenes and tumor suppressor genes. This seminal work has become a paradigm in modern cancer research, with far-reaching implications for future diagnostic and therapeutic strategies.