Jepsen is a former professor at MIT and currently serves as a director at two public companies: LEA and LAZR.She is recognized for her influential contributions to the fields of display technology, imaging, and neuroscience. She has played a pivotal role in developing innovative display systems, including leading projects related to the development of low-cost, high-resolution displays at companies like One Laptop per Child and Google X. Jepsen's work has extended into medical imaging, where she has explored ways to harness technology for early disease detection and brain research. She is also known for her efforts in advancing brain-computer interface (BCI) technology, aiming to create non-invasive methods for reading and interpreting brain activity.