Josef Penninger is a Director of Life Sciences Institute of the University of British Columbia. He is an Austrian immunologist and geneticist known for his research on cancer, immunology, and bone-related disorders. His labdevelop and deploy a broad range of in vitro and in vivo tools that reveal the fundamental mechanisms involved in human disease. These approaches include genetic editing in vitro and in vivo, human induced pluripotent cell (iPS cell) models of disease, haploid cells for genetic as well as compound screening paradigms, mouse and human organoid cultures, as well as genetically engineered mice. Their multidisciplinary techniques enable us to model and study the complexity of human diseases.