Jacob Hanna, a distinguished stem cell biologist at the Weizmann Institute of Science, is renowned for his work in cellular reprogramming and stem cell pluripotency. His interdisciplinary research group focuses on embryonic stem cell biology and organoid modeling. They delve into cellular reprogramming, generating induced pluripotent stem cells, and explore pluripotency maintenance across species. Additionally, they investigate self-organization of stem cell populations into synthetic embryoid models (SEMs) to enhance organ differentiation and study developmental phenomena. Their innovative approach involves using engineered platforms to capture embryogenesis ex utero, from early stages to organogenesis, shedding light on development principles and advancing tissue regeneration. The group employs diverse experimental methods, from genome engineering to computational biology, to comprehensively study these intricate processes.