Benjamin D. Simons is a trailblazing theoretical physicist and biophysicist known for his transformative work in stem cell dynamics and tissue self-organization. Operating from the University of Cambridge, his research employs concepts from non-equilibrium statistical physics and mathematics to uncover the intricacies of stem and progenitor cell behavior in tissue development, maintenance, regeneration, and disease. Through innovative techniques like long-term lineage tracing and single-cell profiling, Simons illuminates stochastic fate decisions and stem cell identity, offering groundbreaking insights into development, tumor initiation, and embryonic symmetry breaking.