Following the completion of his M.D. and Ph.D. degrees, Dr. Jop van Berlo directed his research toward cardiac remodeling and regeneration at the University of Minnesota. His laboratory at the University of Minnesota is dedicated to augmenting the heart's inherent regenerative potential and counteracting remodeling processes. This is achieved through a comprehensive exploration of the mechanisms underpinning endogenous regeneration, along with the discovery of novel regulators governing cardiomyocyte proliferation. Moreover, the lab delves into the intricate interplay between the immune system and cardiac remodeling and regeneration.