Matthias Hebrok is a distinguished researcher renowned for his contributions to the field of pancreatic development and diabetes research at UCSF. His laboratory primarily focuses on the exploration of mammalian pancreas organogenesis and the intricacies of pancreatic diseases, including diabetes and pancreatic cancer. Within this context, the lab meticulously investigates the controlled activation and deactivation of specific signaling pathways, seeking to unravel their profound impact on the functionality, proliferation, survival, and formation of insulin-producing β-cells. Employing techniques such as transgenic mouse models, the team is dedicated to refining methods that enable the generation of fully functional insulin-producing β-cells from diverse human stem cell populations, encompassing human embryonic stem cells (hESCs) and induced pluripotent stem (iPS) cells.