Manuel Serrano is ICREA professor at the Institute Research in Biomedicine in Barcelona. He is a prominent figure in tumor suppression research. Notably, while working at Cold Spring Harbor Laboratory from 1991 to 1996, he discovered and characterized the pivotal p16 gene, integral for anti-cancer defense. Leading research groups at institutions like CNB and CNIO, he identified cellular senescence as a significant anti-oncogenic response, even influencing tissue remodeling during embryonic development. Serrano's exploration expanded into metabolism, reprogramming, and aging, exemplified by his pioneering work demonstrating in vivo cellular reprogramming and his current focus on applying senescence and reprogramming insights to combat degenerative diseases.