Helen Mayberg is a neurologist recognized for her neuroimaging studies of brain circuits in depression and their translation to the development of deep brain stimulation as a novel therapeutic for treatment resistant patients, her work has influenced the development of AI-based therapies for mental health. She had early academic appointments at Johns Hopkins and the University of Texas Health Sciences Center in San Antonio, held the inaugural Sandra Rotman Chair in Neuropsychiatry at the University of Toronto, the first Dorothy C. Fuqua Chair in Psychiatric Imaging and Therapeutics at Emory University and is now the Mount Sinai Professor of Neurotherapeutics at the Icahn School of Medicine where she is founding Director of the Nash Family Center for Advanced Circuit Therapeutics. She is a member of the both the National Academy of Sciences and the National Academy of Medicine as well as the National Academy of Inventors and American Academy of Arts and Sciences.