Laboratory of Integrative and Systems Physiology, EPFL ^{Research Labs}

Laboratory of Integrative and Systems Physiology (LISP) is using systems approaches to map the signaling networks that govern mitochondrial function and as such regulate organismal metabolism in health, aging and disease. LISP applies a state-of-the-art biological toolkit to study a variety of model systems, ranging from the nematode Caenorhabditis elegans and the mouse all the way to humans. Their research has not only allowed the development of new methodologies and scientific approaches applied to population, as exemplified by the development of cross-species multi-layered genetics/omics gene mapping strategies, but also contributed to improved understanding of how signaling pathways control mitochondrial function and metabolism. The translational value of LISP`s work is testified by their successful collaboration with the biopharmaceutical industry and by the fact that several drugs targeting processes and pathways which they elucidated are currently used in the clinic.