1.

Lazard

2.

Life Sciences Partners 1998-01-01

3.

LifeCare Partners 2014

4.

Lloyds Banking Group 1/1/2009

5.

M Ventures 2009-01-01

6.

MassChallenge 2009-06-01

7.

MedHoldings Undisclosed

8.

Michael J. Fox Foundation 2000-01-01

9.

MP Healthcare Venture Management 2006-01-01

10.

Natixis 2006

11.

Neomed Management 1997-01-01

12.

Nestlé Health Science 2011

13.

Nomura Holdings

14.

Novartis 1996-03-22

15.

Novartis Venture Fund 1996-01-01

16.

Novo Holdings 1999-01-01

17.

Odey Asset Management 1991-01-01

18.

Omega Funds 2004-01-01

19.

Palmarium Undisclosed

20.

PMV Tina Fund 2012

21.

PPF Group 1991

22.

Preon Capital Partners Jan 1, 2014

23.

Quest Capital Management 1987

24.

Redalpine Venture Partners 2007

25.

Royal Bank of Canada 1864